Faculty Staff/Section of Animal Biology
Assistant Professor in Biodiversity of Mammals
Office Location: 3rd Floor
Email: npanago@upatras.gr
Telephone: +30 2610 996155, +30 2610 969227 (Lab)

Curriculum vitae


  • 1984: Degree in Biology, University of Patras, Department of Biology
  • 1992: PhD, University of Patras, Department of Biology
  • 1999: Postgraduate Training Certificate in Open and Distance Education

Educational activities

Undergraduate courses:

  • Animal Physiology
  • Neurobiology
  • Environmental Animal Physiology

Postgraduate courses:

  • Molecular Physiology and Neurobiology

Research and other activities

  1. A study of the dopaminergic system and its interaction with other neurotransmitter systems, at the level of receptors and secondary messages, in brain regions of animal models of neurodegeneration and in hypothyroidism.
  2. A study of oxidative status and the association of epilepsy, neurodegeneration, aging and/or electromagnetic radiation (50 Hz) with oxidative stress, by determining levels of oxidative stress markers (lipid peroxidation levels (malondialdehyde, MDA levels) and protein oxidation levels) and thiol redox state (TRS) (glutathione (GSH), glutathione disulfide (GSSG) levels, cysteine ​​(CSH) levels, of protein (P) thiols (PSH) and protein and non-protein (NP) disulfides (PSSR, NPSSR, PSSC, NPSSC, PSSP)) and/or the activity of major antioxidant enzymes (catalase, superoxide dismutase (SOD), non-specific peroxidases (NSPX) and glutathione peroxidase (GPx) before and after administration of antioxidants (N-acetylcysteine ​​(NAC), melatonin, vitamin C, α-lipoic acid, 2-deoxy-D-glucose, 3-O-methyl-D-glucose, etc.), in brain areas or organs of normal experimental animals, epilepsy models (pentylenetetrazol (PTZ) and pilocarpine model), in the weaver dopaminergic neurodegeneration model, in normal aging and after the effect of electromagnetic radiation (50 Hz) in mice.
  3. A study of mechanisms of neurodegeneration and neuroprotection of nigrostriatal neurons in the model of dopaminergic denervation (weaver muscle), after administration of neuroprotective substances (N-acetylcysteine, 17β-estradiol, aspirin) and the neurosteroid BNN 20 or (17-beta-spiro-[5-androsten -17,2′-oxiran]-3beta-ol), a synthetic analog of dehydroepiandrosterone (DHEA), which crosses the blood-brain barrier and lacks endocrine side effects.
  4. A Study of behavioral indicators (anxiety behavior with the open field test) and acetylcholinesterase activity (activity of the two acetylcholinesterase isoforms (G1 and G4)), after seizures (PTZ model), before and after the administration of antioxidants (rutin, N-acetylcysteine, melatonin, 3-O-methyl-glucose, etc.), and with increasing age (13-14 days to 15-16 months), in mouse brain areas.
  5. A study of superoxide radical and hydroxyl radical quantification, and determination of DNA damage in brain and organs (liver, heart, kidney, lung, spleen and intestine) of young and old male and/or female

Research projects

  •  Participation in nine national research projects.

Representative publications

  • N Panagopoulos, N Matsokis, and T Valcana. «Kinetic and pharmacologic characterization of dopamine binding in the mouse cerebellum and the effects of the reeler mutation»J. Neurosci. Res. 19 (1988) 122-129. DOI:10.1002/jnr.490190117 (IF: 4.164, EA: 8)
  • NT Panagopoulos, GC Papadopoulos, and NA Matsokis. «Dopaminergic innervation and binding in the rat cerebellum»Neurosci. Lett., 130 (1991) 208-212. DOI:10.1016/0304-3940(91)90398-D (IF.: 3.197, EA: 80)
  • NT Panagopoulos, NA Matsokis, and T Valcana. «Cerebellar and striatal dopamine receptors: effects of reeler and weaver murine mutations»J. Neurosci. Res., 35 (1993) 499-506. DOI:10.1002/jnr.490350506 (IF: 4.164, EA: 17)
  • NT Panagopoulos, and NA Matsokis. «Pharmacological characterization of [3H]dopamine and [3H]spiperone binding in the mouse cerebellum»Gen. Pharmacol., 25 (1994) 131-137. DOI: 10.1016/0306-3623(94)90022-1 (IF.: 0.91,  EA: 6)
  • N Patsoukis, G Zervoudakis, NT Panagopoulos, CD Georgiou, F Angelatou and NA Matsokis. «Thiol redox state (TRS) and oxidative stress in the mouse hippocampus after pentylenetetrazol-induced epileptic seizure»Neurosci. Lett., 357 (2004) 83-86. DOI: 10.1016/j.neulet.2003.10.080  (IF: 3.197, EA: 158)
  • N Patsoukis, G Zervoudakis, CD Georgiou, F Angelatou, NA Matsokis and NT Panagopoulos*«Effect of pentylenetetrazol-induced epileptic seizure on thiol redox state in the mouse cerebral cortex»Epilepsy Res., 62 (2004) 65-74. DOI: 10.1016/j.eplepsyres.2004.08.005 (IF: 3.045, EA: 45)
  • N Patsoukis, I Papapostolou, G Zervoudakis, CD Georgiou, NA Matsokis and NT Panagopoulos*«Thiol redox state and oxidative stress in midbrain and striatum of weaver mutant mice, a genetic model of nigrostriatal dopamine deficiency»Neurosci. Lett., 376 (2005) 24-28. DOI: 10.1016/j.neulet.2004.11.019 (IF: 3.197, EA 18)
  • N Patsoukis, G Zervoudakis, CD Georgiou, F Angelatou, NA Matsokis and NT Panagopoulos*«Thiol redox state, lipid and protein oxidation in the mouse striatum after pentylenetetrazol-induced epileptic seizure»Epilepsia, 46 (2005) 1205-1211. https://doi.org/10.1111/j.1528-1167.2005.63704.x (IF: 6.740, EA: 37)
  • Κ Botsakis, S Theodoritsi, K Grintzalis, F Angelatou, I Antonopoulos, CD Georgiou, M Margarity, NA Matsokis and NT Panagopoulos*«17β- Estradiol/N-acetylcysteine interaction enhances the neuroprotective effect on dopaminergic neurons in the weaver model of dopamine deficiency». Neuroscience, 21; 320 (2016) 221-229. DOI: 10.1016/j.neuroscience.2016.01.068 (IF: 3.708, EA: 8)
  • K Botsakis, V Tondikidou, N Panagopoulos, M Margariti, N Matsokis and F Angelatou. «Increased sensitivity in the interaction of the dopaminergic/adenosinergic system at the level of the adenylate cyclase activity in the striatum of the “weaver” mouse». Neurochemistry International, 99 (2016) 233e238. DOI: 1016/j.neuint.2016.08.002 (IF: 4.086, EA: 1)
  • K Botsakis, T Mourtzi, V Panagiotakopoulou, M Vreka, GT Stathopoulos, I Pediaditakis, I Charalampopoulos, A Gravanis, F Delis, K Antoniou, D Zisimopoulos, CD Georgiou, NT Panagopoulos, N Matsokis and F Angelatou. «BNN-20, a synthetic microneurotrophin, strongly protects dopaminergic neurons in the “weaver” mouse, a genetic model of dopamine-denervation, acting through the TrkB neurotrophin receptor». Neuropharmacology, 121 (2017) 140-157. DOI: 1016/j.neuropharm.2017.04.043 (IF: 4.999, EA: 14)
  • M Anesti, N Stavropoulou, K Atsopardi, FN Lamari, NT Panagopoulos and M Margarity«Effect of rutin on anxiety-like behavior and activity of acetylcholinesterase isoforms in specific brain regions of pentylenetetrazol-treated mice». Epilepsy & Behavior, 102 (2020) 106632. DOI: 1016/j.yebeh.2019.106632 (IF: 2.937, EA: 14)
  • MA El Mubarak, C Danika, C Cachon, C Korovila, K Atsopardi, NT Panagopoulos, M Margarity, K. Poulas and G. B. Sivolapenko. «In vivo quantification and pharmacokinetic studies of cotinine in mice after smoke exposure by LC-MS/MS». Biomedical Chromatography, 34(2) (2020) e4752DOI: 1002/bmc.4752 (IF: 1.911, EA: 2)
  • DN Zisimopoulos, E Kalaitzopoulou, M Skipitari, P Papadea, NT Panagopoulos, G Salahas and CD Georgiou. «Detection of superoxide radical in all biological systems by Thin Layer Chromatography»Archives of Biochemistry and Biophysics, 716 (2022) 109110. DOI: 1016/j.abb.2021.109110 (IF: 4.013, EA: 3)
  • K Grintzalis**, N Patsoukis, I Papapostolou, G Zervoudakis, E Kalaitzopoulou, CD Georgiou, NA Matsokis, NT Panagopoulos**«Alterations in thiol redox state and lipid peroxidation in the brain areas of male mice during aging». Advances in Redox Research, 6 (2022) 100043. https://doi.org/10.1016/j.arres.2022.100043 (EA: 0)

(IF: Impact Factor (2021)) με αναφορά στη σελίδα του περιοδικού.  ΕΑ: Ετεροαναφορές.

*Αντεπιστέλλων ή ** Συν-αντεπιστέλλων συγγραφέας