Faculty / Section of Genetics, Cell & Developmental Biology
Assistant Professor of Developmental Biology
Office location: 2nd floor
Email: ikazanis@upatras.gr
Telephone: +30 2610 997650
Website: https://www.researchgate.net/lab/Ilias-Kazanis-Lab

Curriculum vitae

Education

  • Degree in Biology (1997), University of Patras, Department of Biology
  • Doctorate (2013), National and Kapodistrian University of Athens, Department of Medicine

Educational activities

  • Undergraduate Courses: Developmental Biology, Neurobiology, Bioethics, General Biology (Department of Physics and Department of Primary Education)
  • Postgraduate Courses: Special Topics in Developmental Biology, Molecular Physiology/ Neurobiology, Βiology of Neural Stem Cells (Department of Medicine)

Research and other activities

  • Biology of embryonic and postnatal neural stem cells.
  • Structure and function of cytogenic zones (stem cell niches) in the postnatal brain (extracellular matrix, blood vessels, ependymal cells).
  • Ageing, hypoxic/ ischemic injury, demyelinating diseases.

Funding

Representative Publications

  • Anesti M, Magkafa S, Prantikou E, Kazanis I. (2022) Divergence between Neuronal and Oligodendroglial Cell Fate, in Postnatal Brain Neural Stem Cells, Leads to Divergent Properties in Polymorphic In Vitro Assays. Cells, 11, 1743. https://doi.org/10.3390/cells1111174
  • McClenahan F*, Dimitriou C*, Koutsakis C, Dimitrakopoulos D, Arampatzis A, Kakouri P, Kourla M, Oikonomou S, Andreopoulou E, Patsoni M, Meri DK, Rasool RT, Franklin RJM, Kazanis I. (2021) Isolation of neural stem and oligodendrocyte progenitor cells from the brain of live rats. Stem Cell Reports, 16(10):2534-2547. doi: 10.1016/j.stemcr.2021.08.015
  • Mourtzi T, Dimitrakopoulos D, Kakogiannis D, Salodimitris C, Botsakis K, Meri D-K, Anesti M, Dimopoulou A, Charalampopoulos I, Gravanis A, Matsokis N, Angelatou F, Kazanis I. (2021) Characterization of substantia nigra neurogenesis in homeostasis and dopaminergic degeneration: beneficial effects of the microneurotrophin BNN-20. Stem Cell Research and Therapy, 12(1), Article number 335, 10.1186/s13287-021-02398-3
  • Kazanis, I., Evans, K., Andreopoulou, E., Dimitriou, D., Koutsakis, C., Karadottir, T., Franklin, R. J. (2017) Subependymal Zone-Derived Oligodendroblasts Respond to Focal Demyelination but Fail to Generate Myelin in Young and Aged Mice. Stem Cell Reports, e-pub 9 Feb. 2017, 10.1016/j.stemcr.2017.01.007
  • Kazanis, I., Feichtner, M., Lange, S., Rotheneichner, P., Hainzl, S., Öller, M., Schallmoser, K., Rohde, E., Reitsamer, H. A., Couillard-Despres, S., Bauer, H. C., Franklin, R. J., Aigner, L., Rivera, F. J. (2015) Lesion-induced accumulation of platelets promotes survival of adult neural stem / progenitor cells.  Exp Neurol, 269, 75-89. doi: 10.1016/j.expneurol.2015.03.018.
  • Chandran, J. S., Kazanis, I., Clapcote, S. J., Ogawa, F., Millar, J. K., Porteous, D. J., & ffrench –Constant, C. (2014). Disc1 variation leads to specific alterations in adult neurogenesis. PLoS One, 9(10):e108088. doi: 10.1371/journal.pone.0108088
  • Kazanis, I., Gorenkova, N., Zhao, J-W., Franklin, R. J., Modo, M., & ffrench-Constant, C. (2013). The late response of rat subependymal zone stem and progenitor cells to stroke is restricted to directly affected areas of their niche. Exp Neurol, 248, 387- 397. doi: 10.1016/j.expneurol.2013.06.025
  • Kazanis, I., & ffrench-Constant, C. (2012). The number of stem cells in the subependymal zone of the adult rodent brain is correlated with the number of ependymal cells and not with the volume of the niche. Stem Cells Dev, 21(7), 1090-1096. doi:10.1089/scd.2011.0130
  • Kazanis, I. Can adult neural stem cells create new brains? Plasticity in the adult mammalian neurogenic niches: realities and expectations in the era of regenerative biology. (2012). Neuroscientist, 18(1), 15-27. doi:10.1177/1073858410390379
  • Kazanis, I., Lathia, J. D., Vadakkan, T. J., Raborn, E., Wan, R., Mughal, M. R., et al., & ffrench-Constant, C. (2010). Quiescence and activation of stem and precursor cell populations in the subependymal zone of the mammalian brain are associated with distinct cellular and extracellular matrix signals. J Neurosci, 30(29), 9771-9781. doi:10.1523/JNEUROSCI.0700-10.2010
  • Kazanis, I. (2009). The subependymal zone neurogenic niche: a beating heart in the centre of the brain: how plastic is adult neurogenesis? Opportunities for therapy and questions to be addressed. Brain, 132(Pt 11), 2909-2921. doi:10.1093/brain/awp237
  • Kazanis, I., Belhadi, A., Faissner, A., & ffrench-Constant, C. (2007). The adult mouse subependymal zone regenerates efficiently in the absence of tenascin-C. J Neurosci, 27(51), 13991-13996. doi:10.1523/JNEUROSCI.3279-07.2007
  • Ekonomou, A.*, Kazanis, I.*, Malas, S., Wood, H., Alifragis, P., Denaxa, M., et al., & Episkopou, V. (2005). Neuronal migration and ventral subtype identity in the telencephalon depend on SOX1. PLoS Biol, 3(6), e186. doi:10.1371/journal.pbio.0030186 (*authors equally contributing)