Project Description

Faculty / Section of Genetics, Cell & Developmental Biology
Lecturer
Office location: 2nd floor
Email: ikazanis@upatras.gr
Telephone: +30 2610 997650
Website: https://www.researchgate.net/lab/Ilias-Kazanis-Lab

Education

  • Degree in Biology (1997), University of Patras, Department of Biology
  • Doctorate (2013), National and Kapodistrian University of Athens, Department of Medicine

Educational activities

Undergraduate Courses:

  • Developmental Biology
  • Neurobiology
  • Molecular Genetics
  • Molecular Biology I
  • Bioethics
  • General Biology

Postgraduate Courses:

  • Special Topics in Developmental Biology
  • Molecular Physiology/ Neurobiology

Research and other activities

  • Biology of embryonic and postnatal neural stem cells.
  • Structure and function of cytogenic zones (stem cell niches) in the postnatal brain (extracellular matrix, blood vessels, ependymal cells).
  • Ageing, hypoxic/ ischemic injury, demyelinating diseases.

Funding

Representative Publications

  • McClenahan F, Dimitriou C, Koutsakis C, Dimitrakopoulos D, Arampatzis A, Kakouri P, Kourla M, Oikonomou S, Andreopoulou E, Patsoni M, Meri DK, Rasool RT, Franklin RJM, Kazanis I. (2021) Isolation of neural stem and oligodendrocyte progenitor cells from the brain of live rats. Stem Cell Reports, 16(10):2534-2547. doi: 10.1016/j.stemcr.2021.08.015
  • Mourtzi T, Dimitrakopoulos D, Kakogiannis D, Salodimitris C, Botsakis K, Meri D-K, Anesti M, Dimopoulou A, Charalampopoulos I, Gravanis A, Matsokis N, Angelatou F, Kazanis I. (2021) Characterization of substantia nigra neurogenesis in homeostasis and dopaminergic degeneration: beneficial effects of the microneurotrophin BNN-20. Stem Cell Research and Therapy, 12(1), Article number 335, 10.1186/s13287-021-02398-3
  • Kazanis, I., Evans, K., Andreopoulou, E., Dimitriou, D., Koutsakis, C., Karadottir, T., Franklin, R. J. (2017) Subependymal Zone-Derived Oligodendroblasts Respond to Focal Demyelination but Fail to Generate Myelin in Young and Aged Mice. Stem Cell Reports, 8(3):685-700. doi: 10.1016/j.stemcr.2017.01.007
  • Kazanis, I., Feichtner, M., Lange, S., Rotheneichner, P., Hainzl, S., Öller, M., Schallmoser, K., Rohde, E., Reitsamer, H. A., Couillard-Despres, S., Bauer, H. C., Franklin, R. J., Aigner, L., Rivera, F. J. (2015) Lesion-induced accumulation of platelets promotes survival of adult neural stem / progenitor cells.  Exp Neurol, 269, 75-89. doi: 10.1016/j.expneurol.2015.03.018.
  • Kazanis, I., Gorenkova, N., Zhao, J-W., Franklin, R. J., Modo, M., & ffrench-Constant, C. (2013). The late response of rat subependymal zone stem and progenitor cells to stroke is restricted to directly affected areas of their niche. Exp Neurol, 248, 387- 397. doi: 10.1016/j.expneurol.2013.06.025
  • Kazanis, I., Lathia, J. D., Vadakkan, T. J., Raborn, E., Wan, R., Mughal, M. R., et al., & ffrench-Constant, C. (2010). Quiescence and activation of stem and precursor cell populations in the subependymal zone of the mammalian brain are associated with distinct cellular and extracellular matrix signals. J Neurosci, 30(29), 9771-9781. doi:10.1523/JNEUROSCI.0700-10.2010
  • Kazanis, I.,Belhadi, A., Faissner, A., & ffrench-Constant, C. (2007). The adult mouse subependymal zone regenerates efficiently in the absence of tenascin-C. J Neurosci, 27(51), 13991-13996. doi:10.1523/JNEUROSCI.3279-07.2007
  • Ekonomou, A., Kazanis, I., Malas, S., Wood, H., Alifragis, P., Denaxa, M., et al., & Episkopou, V. (2005). Neuronal migration and ventral subtype identity in the telencephalon depend on SOX1. PLoS Biol, 3(6), e186. doi:10.1371/journal.pbio.0030186 (*authors equally contributing)